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Google has an offline gmail version in beta. Requires Google Gears (not available for FF3.5, last I checked) but works for Safari.

All my mail is synced locally but I can still use the Gmail interface.

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Me too - using Gmail + Gears w/ Safari 4 Fluid app, and a dock badge 'inbox count' userscript. Google will tell you you can't install gears with safari 4 - but it works.

it doesn't sync all your mail.

It is available for Firefox 3.5 and it does sync all your recent mail, including attachments. It uses an automatic, non-configurable heuristic to determine how much mail to sync. I believe mine syncs the past 1 year's.

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