One one hand I'm happy to see the web able to do more and more. On the other hand, I worry that as we turn the browser into a platform with all these client side capabilities, browsers will become big complicated messes.
They aren't already?
Click once deployment for .NET applications as another example.
And they are non starters for demanding multimedia work, which is some of the most interesting stuff you want to do in the desktop as opposed as a web app.
.NET feels better (because MS didn't screw up as much, as Java did with the overengineered uncanny valley mess that is Swing), but it's not cross platform.
So, still, not comparable to deploying in the browser sandbox.
That much is true, I haven't yet used so brain damaged set of programming tools as the HTML/JavaScript/CSS gimmick required to make the so called web applications in all browser versions required by our customers.
Good luck with mobile and set top box browsers.