It's all Turing machines/lambda calculus at the bottom, right?
Javascript is slower, sure, but (with recent developments) not that much slower.
The porting issues involved with making something work cross-browser are much less than the porting issues we used to face in making something work on (e.g.) MS-DOS and Mac. With JS the UI needs tweaking. With MS-DOS and (classic) Mac OS you had to do a full rewrite from scratch.
Things are arguably getting a lot better.