Facebook: MVC Does Not Scale, Use Flux Instead
infoq.com
infoq.com
If you're trying to push an api layer into MVC you're probably going to run into problems at any kind of scale because your application doesn't end there, it goes through into the client layer and loses control of how data is represented.
Keen to hear any other thoughts on this but that is my view.
Put 54gb of code into any framework and you're going to run into "scaling" issues.