If you enable case sensitivity on OSX filesystem, adobe photoshop won't install.
http://helpx.adobe.com/creative-suite/kb/error-case-sensitiv...
http://helpx.adobe.com/creative-suite/kb/error-case-sensitiv...
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why would you do that to yourself!?
A good example would be MySQL. The case sensitivity of table names is determined by the file system on which MySQL is running.
It's terrible, I know, but if you're developing a webapp which is going to run on a Linux-server you might want to have a case sensitive database locally as well or you could end up with queries that run without a hitch on your dev machine but give a "No such table" error in production. That sucks.
Of course, nowadays, you could just use a Vagrant VM or something similar, but still.