From the article:
Rhinehart is well aware of the fact that Soylent
isn’t the first beverage designed to replace meals.
He considered using Ensure for his initial no-eating
experiment, but found it much too expensive, too sugary,
too unpalatable, and sub-optimal in its ingredient
make-up.
The differentiating factor seems to be in the intended
purpose. Meal-replacement shakes have never been
presented as a food — something that you could (or
might want to) live on for an extended period.