Compared to what? Please be specific in your definition of "slow."
>Runtimes like PyPy is where we should be looking, since they implement the full Python language and are fast.
Why should 'we' be looking to PyPy? Have you run a non-trivial application with pypy (v. standard cpy) and found it to be significantly faster?
Even if your code would benefit from JIT, and your code is compatible for running on PyPy, does it benefit more from a compiler switch than CPython + Pandas?