In the example given with the element:hover and element:active, it would trivial to parse all possible CSS transforms. Then live profiling of the page would give data on the likelihood of particular transforms. The browser could then optimise as necessary given hardware limitations and current resource constraints. Even transforms added via javascript or onhover would be caught via live profiling.
The given use case of stopping flickering when a layer is created should be treated as a bug.
This feels hacky, and likely to be used erroneously or abused - at which point browser will be forced to smartly ignore leaving us with yet more cruft. Performance tuning is a fine art, and browser is in a better position to do it vs your average web developer.