EVERYTHING.
When you throw away the entire rocket every flight you throw away tens of millions of dollars in hardware. If you can recover and re-fly stages you can get away with a lot of compromises elsewhere. Especially since the first stage, for SpaceX anyway, represents 3/4 of the hardware cost of the launch vehicle.
Even reusing the first stage once means cutting the overall hardware cost of a flight by nearly 1/3. For SpaceX that translates to about $20 million per flight in savings. And that's from one and only one reuse flight of the first stage. In comparison the fuel is nothing. In comparison even a massive payload hit is acceptable. As long as the payload reduction is less than the cost reduction, everything is golden, and the rest is profit margin. For 2 reuses (3 total flights) the hardware cost per launch drops to 1/2 of current costs. For 5 or more uses per first stage the cost drops below 40%.
SpaceX's launches are already cheaper than the competition, dropping below 1/2 of their current cost floor makes it impossible for the competition to keep up and would enable them to own the launch market.