I've written a fair amount of Haskell, and done a lot of this type of optimization, looking at the core (intermediate representation) and fiddling with pragmas, unboxing, strictness, etc. I've put Haskell on the back burner and gone back to C++ because I spent SO MUCH time doing this. Maybe I'm not being fair, and in another 5 years I'd be able to predict what GHC is going to do as well as I can predict what a C++ compiler will do. But for now, I can't justify the expenditure in time it takes to get a large piece of Haskell code (more than a microbenchmark) to perform at the C/C++ level. If you write idiomatic Haskell you're tracking down stack overflows (the Haskell kind, not the C kind) and misfired optimizations, and if you're writing C-in-Haskell you're better off just writing C. In the end, I think Haskell just isn't (yet) the best language for what I was doing (image processing, graphics, 3d modeling, etc.)
(The short reply to your comment is: yes, you the application writer have to be very aware of what GHC is doing if you want C-level performance.)