But that doesn't mean a mutated strain could potentially befall the whole world. The same goes for the more terrifying types of the flu. There is always the potential for a deadly and extremely contagious pathogen to develop.
So what to do in a pandemic situation? I'm hesitant to admit it, but basically the survivalists have it right: hole up somewhere off the beaten path and avoid all outside contact, that potentially includes all kinds of animals like birds and livestock. Then you'll have to wait until a vaccine is developed. If a vaccine is feasible.