The fact a user might have installed from somewhere other than the webstore, or if they're on Safari or IE, is entirely irrelevant - the 326k is
active users, eg people who have accessed the Rapportive API in the last week. That's
everyone using Rapportive regardless of where they installed from or which browser they're in.
Whether or not Rapportive is limited by GMail is a good question. Getting 0.065% market penetration after 4 years would worry me, but doesn't mean they weren't making giant piles of cash. You could easily run a profitable business with 326k users even if only a tiny proportion are paying something. The important thing to take away from Rapportive's numbers is that a huge market doesn't automatically translate in to a huge market of available customers for your product. There might only be a tiny proportion who want what you're offering. Fortunately that doesn't actually matter if you can run your business profitably anyway.