If you want to look at devastating datacenter loss, if anything happened to Northern NJ the markets would go into a tailspin.
I'm just tired of the obviously incorrect proposition that Bay Area is producing just frivolous photo sharing and social communication tools (which both has a huge value for humanity, but that's a different story) and I seriously find it an interesting thought experiment what would happen on a global scale if the Bay Area would be devastated by a big earthquake.
The obvious tech giants like Google, Apple, Oracle and Cisco are arguably supporting a huge number of businesses and organizations around the world. But a glance through a list of just publicly traded US SaaS companies reveals that about 40% are from the Bay Area. These offer SaaS-based solutions ranging from HR tools (Workday), IT service monitoring (Splunk), ITMS (ServiceNow), CRMs (SalesForce), ERPs (NetSuite), Insurance backends (Guidewire) to supply chain management (e2open), to just name a few.
If Bay Area suffered anything resembling 2008 Sichuan earthquake, it would halt a good part of the economy for a while.