Its a very common phenomenon in science that a finding is published in a glamour journal e.g. Nature/Science and then if not immediately controversial e.g. acid bath stem cells, it becomes very difficult to publish something contradictory.

Journal referees will set the bar for such findings very very high...and you are quite likely to be refereed by the original author or their friends.

I know this to my cost having gone to extraordinary lengths to publish something slightly contradictory in a far lower impact journal than the work deserved.