Given the recent abundance of jQuery alternatives, that's a big assumption to make. It's always disappointing when I find some code I want to use and it has a bunch of dependencies that make it not an option.
That said, it does everything jQuery does, and more, and in a very nice way IMHO. If you're used to the jQuery syntax sugar, you probably don't like it, but I never liked sugar.
So yeah, a jQuery dependency is a killer for me.