If you want the highlights, this economist article does as decent a job of summarizing 400+ pages as you can hope for in 4 paragraphs.
http://www.economist.com/blogs/economist-explains/2014/05/ec...
As for the content, the main take away, is his r > g argument which is illustrated by the following chart:
http://piketty.pse.ens.fr/files/capital21c/en/pdf/F10.9.pdf
One of his other big ideas Bill hits on is his tax on captial. Bill proposes a tax on consumption instead.
> But rather than move to a progressive tax on capital, as Piketty would like, I think we’d be best off with a progressive tax on consumption.
Maybe not surprisingly since I work in finance, most of my colleges are on Bill's side and not Piketty's here. To be fair to Piketty, he chose a tax on capital because he's coming from a perspective of how do we prevent the accumulation of wealth over generations, where as Bill is coming at it from how do we raise enough taxes to pay for the the services the government needs to provide.
I would recommend reading this book, its clearly a labor of love for him and he's spent the time to back it up with data, just don't expect to agree with all his conclusions.