Totally! Arcadia is based on the Clojure-CLR port (an official project) maintained by David Miller for five years or so. It supports Mono.
We had to fork the compiler to introduce a small number of changes to make Arcadia work in Unity, though. Unity ships a very old version of Mono with their own changes, so stock Clojure-CLR would not work.
https://github.com/clojure/clojure-clr https://github.com/arcadia-unity/clojure-clr