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With respect, your idealised assessment still has the problem with how that translates to depression, or (after) lack there of.

Definitely agree that our understanding is only really beginning in these kinds of areas though ultimately you are often going to be treating a disorder of subjective experience with these drugs. That makes it very hard for us not to be wishy-washy these days

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I feel like the points you two are stating work best in concert. We do need to start asking more empirical questions about "what is depression in this person" and obviously can't do that without substantial amounts of data to drive our investigation, and this is where I agree with the original post that we're very lacking. To me at least, the first step in handling something subjective is trying to define it, and for that we need to better understand it.

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