I've run into a situation where I was able to sign up using the + in the e-mail, but not login (or unsubscribe from their newletter) with the same address.
This was a pretty fringe service of negligible value to me, so when my CC changed I sent them an email telling them of this problem, and my inability to change my account. No response.
So I let the account expire. Still couldn't believe that a team could make a new presentation that blocked already in place usernames, nor would they do anything about it.
As a mediocre web dev, that'd be my next step.