I don't believe he said it makes no difference.
As long as you are concerned with adding a bit of eye candy and interactivity to a web page this may be true enough to get away with the JavaScript way of making every number a double precision floating point number but there a other domains where this will not fly. And even in the world of JavaScript asm.js is trying hard to overcome this limitation.
Sure, and I believe everybody, including Doug, knows this not so subtle distinction. He wasn't talking about programming HPC for NASA.