I'm actually going through and setting up KeePass with two factor auth (just using Google's Authenticator app for now, maybe a yubikey in the future) right now and have a similar question. After looking into KeePass and kicking the tires a bit I really, really wish someone would step in and make a nice cross platform version to simplify setting up a password store with two factor auth and other best practices (long pass phrases, etc.).

Right now from what I see it's a horrible mish-mash of different apps on different platforms written by different people with an unknown level of support for each of them. Frankly I don't even know if most of the KeePass apps are compatible with each other, and that kind of scares me. Setting up two factor access to KeePass is also pretty obtuse and requires tracking down blog posts and such to figure it out.

I don't mean to denigrate any of the contributions or work people have done in this space (in fact I am incredibly thankful), but it does feel like some leadership to put all these pieces together is badly needed.

I would absolutely love and be more than happy to spend some money on a polished app that's cross platform and is 'batteries included' so you can setup two factor auth & use devices like yubikeys without any extra screwing around. Bonus points if it doesn't require Mono too.