Neither are areas where any business would establish itself, because most all of Oakland are old fashioned post-war neighborhoods. Downtown Oakland, and the meat of the city's desk & cubicle type of office spaces are in the center near the lake and the bridge. This is a very small area without a whole lot of commercial development starts, current or planned. A surprising amount of high density residential real estate priced for upper-middle class types are slowly appearing. These projects are eating away at the old retail/warehouse space that would typically be turned into new commercial development. There is an alternate universe where Twitter moved to Oakland/Emeryville and brought the mid-Market/Castro-East craziness with it...
[Also, there is plenty of violent crime throughout the Valley. It doesn't show up very well in crime statistics and reports because how closely intertwined it is with the poor, semi-homeless and meth. Nobody likes to talk about it, and it is very good at hiding in the bushes (literally).]