I've used it, but doesn't seem like it's being maintained. Another option seems to be to start chrome with --proxy-server="socks5://127.0.0.1:2001" --host-resolver-rules="MAP * 0.0.0.0 , EXCLUDE 127.0.0.1", then run a SSH tunnel with -D 2001 to some SSH host you control.
Yeah, unmaintained indeed. sshuttle doesn't work at all on OS X anymore, as it expects to find ipfw, and doesn't support 10.10's pf firewall.
Just as well, really; ipfw was deprecated for awhile, and sshuttle was a pretty good way to trigger kernel panics on 10.9.