With es6 around the corner and the possibilities those features will provide, i would still bet on pure js. Those precompilers will benefit a great deal too. Symbols and Proxies alone will remove a lot of the hoops they have to go through now.
I don't get this argument on the size of a hello world, given that JQuery 1.11 is over 270 KB and most people are just doing simple DOM selection with it, yet they don't complain their hello world comes with 270 KB of stuff they'll never use. Factor in React, Bootstrap, Angular.js or what have you and you can easily reach 1 MB of stuff that's never used for a couple of lines of code.
The app doesn't explode in MB, unless those MB are really needed - which is the fundamental difference between how these work and regular Javascript development. And given that there are some companies using these in production for non-trivial stuff and that nobody has ever reported that, I'm thinking that it doesn't happen.
My current app is currently clocking at 300 KB btw, but I am using the collections from the standard library, I am using a library for reactive streams built by myself, I am using React and I do have some code in it. And personally I find it OK.