Try reading Infinite Jest on a Kindle. Half of the book is in the end notes.
But no, I'd never read a textbook on a Kindle. Can't flip around.
I look at how Grantland has adjusted to using footnotes, since several of their writers (Bill Simmons, Chuck Klosterman) were influenced, in some part, by Wallace and utilize lots of footnotes, and think it's a decent experience on desktop, but not that great on mobile devices.