Before the release of 2.1.0, funny_falcon, samsaffron and I developed a patch that removes the global method cache in favor of a local method cache inside each class. (This was originally proposed for upstream inclusion in https://bugs.ruby-lang.org/issues/9262).

The patch has been running in production on GitHub's servers for over a year, and provides the benefits of a high cache-hit rate without the need for manual tuning. I recently ported this patch to ruby 2.2 as well and it is available in this squashed commit: https://github.com/github/ruby/commit/bd002fc9fc3c7236395df2...