I used to study in a big open, well lit room at the university library that was filled with people, but very quiet, and it was fine.
You would have to establish a culture of seriously chewing out people for making noise. The problem is, introverts are not likely to do that.
The only other factor is everybody has to have a proper wall to their back. Something in the mamillian brain freaks out when there are people moving about at your six.