Personally, I have found NoScript for be sufficent for my needs. I don't mind advertising, but what I do mind is ads that pop-up, animate, or move. NoScript seems to take care of most of these.
Afaict, there is a single checkbox to click ('Allow some non-intrusive advertising') to not see white listed ads. I do not see ads from Google, MS, etc. when it is unselected.
I have the box checked and I recently started seeing Youtube ads.
I've been using a combination of Ghostery and EFF Privacy Badger to some decent success.