How about running Scala in multiple threads? And how about dealing with structurally-shared data?
Also, all of Scala's collections, including the persistent ones are supported.
Yes, I know most JS programs today use asynchronous execution successfully in practice, but to use it as the basis of a language platform is not a good idea IMHO. Especially when it comes to UIs, which need the responsiveness.
EDIT: web-workers are not a solution, because you can't share large data-structures efficiently between web-workers.