The mass ratio of the Space Shuttle is 16 according to wikipedia[0]. As far as I know, all orbital rockets that we've built have mass ratios similar to this. That's higher than we'd like, but reasonably practical to build.
According to the linked chart, the propellant mass required to get a canister the size of the space shuttle payload to Alpha Centauri without stopping in 900 years using a fusion rocket is 10^11kg. I'm not sure what mass they're using for that shuttle payload canister, but let's say that it's the Wikipedia-claimed shuttle payload to LEO[1] of about 25,000kg. That gives us a mass ratio of about 4000000 by my calculation. Uhh yeah, you wanna build a spaceship with a mass ratio of 4000000? I tried plugging that in versus the mass of a Nimitz-class carrier, and I'm getting the mass of a smallish moon.
And that still doesn't count stopping at the end, or getting anywhere near 0.1c. Sounds like if you want to propel a reasonable-sized starship at the speeds you said, you're gonna need roughly a gas giant worth of fuel. If you know of way around that, please let me know.
[0] http://www.wikiwand.com/en/Mass_ratio [1] http://www.wikiwand.com/en/Space_Shuttle