If you cannot be surprised while the drive is mounted, and cannot be compelled to mount it (maybe just by booting the machine) then there is no known specific additional risk to running FDE.

Note that "surprised" might include a networked attack, in addition to being tackled in a coffee shop.

File-level encryption protects your data until you reach the court order level of compulsion, and possibly further. At least in civilized countries.

So, given those caveats, I'd say your answer is "yes", but...the best plan is to do both. FDE as a matter of policy, and file-level on any files of specific value.