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It's already been used in larger animals. http://www.nature.com/nprot/journal/v9/n8/full/nprot.2014.13...

I know there is one paper that describes curing a liver disease (in a mouse I think) using CRISPR-CAS but I can't find the reference right now.

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I can't remember the details of this either, but as I recall it was done in liver because when you inject DNA into mice the liver basically filters it all out, so you get very high efficiency in the liver, but no where else!

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