In STEM, I have the very strong impression that there are many paths that will take you off the academic track, and essentially none that will get you back on it. E.g. you have to keep up with the current literature to some degree.
I've heard of one example of that in the MIT AI Lab in the '60-70s, although it helped that "very successful" can equal "can pay for his research budget" ^_^. And of course there weren't many real CS graduates to turn into faculty members in the bad old days.