There's an awfully optimistic bit in REAMDE about an overweight fantasy author transforming into 'Skeletor' via a treadmill desk.
I agree, Skeletor is an oversale of the health benefits but as common knowledge, the further you are from your ideal weight, the easier to is to lose weight and balanced with proper eating habits, its not unreasonable to suggest that a walking desk is would slim someone down, especially if aided in other exercise outside of work.
Disclaimer: his books are like crack to me. Once I start one I can't put it down and now have carefully choose when to pick one up. Quicksilver is next up over the summer.