Not when I'm on some tiny VM or computer and want something nicer than Nano that has something remotely close to Emacs keybindings. Then it's the keybindings, not the scriptability. I just want a reasonable editor.
In my experience it highly depends on the editor. With Sublime Text 3 on OS X, each keystroke is delayed by SSHFS' latency. It's a pain.
Tramp transfers the files back and forth, always working on a local copy (if I remember correctly). It provides a better experience.
Some of the most frequent operations, like switching between buffers or windows takes 3 key strokes!
It can take more keystrokes than that, even, if you have three or more windows.