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Not really, for interactive UI development you need to model the UI as a pure function (no state in the view). So that limits you to React or React-like approaches, and game engines: https://www.youtube.com/watch?v=tJr_TD1BtF0

For backed web development (in Clojure at least) there isn't really a lot of state in the first place - request comes in, request comes out, state is in the database not the application - so there are no framework constraints.

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Depends on the backend platform actually. Apache CGI processes (PHP) are fire-and-forget per request. But for example Ruby and Node.js servers persist through request cycles. It's important that any state is unique to the request, sometimes even the caches should be per request.

Node.js has a package called piping that hot-reloads require()ed files. It makes interactive development possible. Checkout my backend and frontend interactive isomorphic starterkit: https://github.com/RickWong/react-isomorphic-starterkit It hot-reloads Node server code and client code your browser.

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