There remain some big tests, among them: Can we accumulate and release enough energy to take us to the stars without having a civilization-ending war with ultra-destructive directed energy weapons? Can we avoid mistakes in modifying life, and in nanotech, that would cover the planet in goo? Can we master germline modifications of humans without doing something that ends with no humans, and no post-humans? So plenty of filter to go yet. Never mind the smaller-scale "do we have way too many humans already to not overheat the planet we're on?" questions.