Every time they ask me that question - I do a quick mental checklist, always mention that my luggage did leave my control when placed in the boot of the cab - which they always understand is an acceptable loss of control.
There are a couple alternatives that one could take to further increase security - first, presume that 100% of people are threats, and do a full security scan, and hand check/rejection, of 100% of checked luggage. Likewise, enhance the carry-on security check, and further restrict what people can carry-on. In particular, shift the carry-on check to the gate (where it should be).