You can write Ember/Angular/Knockout etc... in ClojureScript (I've done it before) but it comes out feeling weird and unnatural. You always feel like you're trying to fit a square peg into a round hole.

The preferred solution is to use a ClojureScript wrapper around ReactJS and write your own event handling logic. I'm a big fan of the Reagent library which wraps React with a dead simple API. I believe it's the best UI library ever created and I wish more people knew about it.

The big idea is that you store your UI state as one single Clojure data structure. A Reagent component is just a Clojure function that takes the necessary sub-section of the UI state as an argument and returns a Clojure data structure that represents the HTML code that it wants to render. An example of this would be the following component that displays a list of items.

(defn [items] [:ul.items (for [item items] [:li.item (:display-name item)]])])

Then whenever you change the state of 'items', the component will automatically re-render and inject the new DOM as necessary using React's diffing algorithm for high performance. The key thing here is that there is no Javascript framework to learn. All you do is manipulate Clojure data with Clojure functions and use React to render it. There's no 'Ember.component.extend' or 'ng-repeat' to worry about. You spend very little time looking through documentation. The Clojure langauge IS your framework, it's really incredible.