Visual Studio 2010 and the dotNet Framework work fine in WINE: https://appdb.winehq.org/objectManager.php?sClass=applicatio... . VS run as early as 2003 in ReactOS: http://virtuallyfun.superglobalmegacorp.com/wordpress/wp-con...
As ReactOS also supports the Windows graphic card driver from NVidia, AMD and Intel - it's for sure an upcoming alternative to Windows. http://en.wikipedia.org/wiki/ReactOS . Beside that more and more Indie-game-developers support Mac & Linux (PR via Humble Bundle), and beside Indie: GOG and Steam (http://en.wikipedia.org/wiki/Steam_Machine_(hardware_platfor... ) are going strong too.