2) IMO a much more stringent form of peer review is necessary. P<0.05 is only useful in very limited situations. I would argue that unless you republish your exact experimental design beforehand you would need to drop that to P<.01 to cover for a lot of marginal research out there. The old do 10 studies and you can likely publish one of them is harder when you need to do 50 or fudge the numbers harder.