Every day. But then I look at my children, remember the work I've done that I'm most proud of and stuff like that and I shrug it off.
Sure, I would love to be more socially engaged in my surroundings, but whenever I'm in doubt about my life I reevaluate my priorities and usually discover that I'm pretty happy where I'm at. It's my life and I get to define the optimum, and so far viral content, insta-fame and richness hasn't gotten close to the top.
Caveat: I'm not famous, haven't founded a start-up or famous for my twitter debates. But it works for me.