I hope you don't mind my running this by you all. If I'm asked this question, I will respond that my biggest weakness is that I'm coming from academia.

I believe that many hiring managers will consider this a problem, or at least a potential problem. I believe it may be a good answer anyways because 1) it doesn't actually tell them anything "bad" that they didn't already know, and 2) it signals that I am aware that working in their company won't be the same as academia and that my being aware of this makes me more likely to be able to adapt.

Any thoughts or criticisms?