Most personal gasoline cars last approximately 200,000 miles, but people rarely keep them that long because for the average driver the car is 10-20 years old. The interior will wear out long before the engine. If the car manufacturers built the drivetrain to last 400,000 miles, they would just be wasting money.
If the car is running 24/7 at 30 mph, you would top 250k miles per year. I imagine they will design the cars to last more than a year, potentially a few, so 750,000 miles is not off the table.
Also in the world where a car is an autonomous income producing asset, initial cost matters a lot less and total lifetime cost matters a lot more. Businesses will do the math and buy vehicles that minimize their cost. Automotive engineers will put more effort into reliability because fleet owners will have data to measure.
It's a different world. A lot of our current assumptions will get rethought.
Unless someone finds an economic activity that you can throw basically unlimited car-hours at in the night time. The yield can be low, but it has to be higher than the variable cost of one more car hour.
I can't think of a car I, or my family, have owned which hasn't lasted at least twice that long.
My current car is a 2002 BMW E39 530D. It has almost 900,000 kms on the clock and is still going strong on the original engine. The cloth interior is still in quite reasonable condition. There has of course been the need for minor maintenance (rear shocks were required at the last inspection). Right now I need new door seals and there is some minor rust attended to. However, at a consumption of approximately 7 liters per 100 km on the autobahn, I don't see any need to buy a newer car for quite some time yet.
The issue is if it's poorly maintained or it's abused, or if it's not well built. And a sizable percentage of cars in the fleet fall into at least one of those categories. The number that we need to worry about from a policy perspective is not the life of the car in the best case scenario, it's the life of the car in the expected scenario.
https://youtu.be/HnQs1k_0Yys?t=29m36s
The speaker is Stefan Heck from the Precourt Instute for Energy at Stanford. No citation, so I guess it's just math he did.
I assume they're factoring in some reasonable price drop. I would expect the vast majority of self-driving cab rides will be in two-seaters like the Smart Car, which starts at $12,000. You'd buy them wholesale, so it should be even less than that. Not to mention you can get rid of the entire steering column, etc. At $10,000 per vehicle, you only need to drive 125,000 miles to break even.
Look at taxis/Uber and think about what portion of the cost is licensing (Uber's cut in their case), wage and fuel.