I wish this had been included in the main body of this post, with some metrics; everyone you know uses it because it makes the web suck so much less.
Loading The Verge's article in a Chrome incognito window: 19.6 MB transferred, finished in 41.9 s, huge ad covering the entire page above the developer console I had open to watch things load.
Same article in a new incognito window with Adblock Plus enabled: 1.5 MB transferred, finished in 16.94s.
Screenshots: https://twitter.com/jbscript/status/624535428620791808