In this day and age, Adblock is a necessity for nontechnical users. I installed it on my parents' machines to protect them against drive-by-downloads, malware, etc.
Someone may say, "I know my ad networks would never do anything of the sort". But the fact is, ad networks get compromised, and even ad networks that have strict policies for acceptable ads sometimes have bad actors slip through. Even if it's not often, it's enough of a risk that it's simply not worth it.
FWIW, Reddit may be in a different situation, since I believe Reddit's ads are self-hosted. In that sense, I'd view it more as analogous to sponsored user-generated content, which I have other philosophical issues with, but don't suffer from this problem.