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40four

2,620 karma · joined January 16, 2018

Web Application Developer
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40four··on PlayStation Is Deleting 551 Movies from Customers' Accounts
Makes me glad I never got in the habit of buying digital copies of movies or TV shows. This a one off many reminders that if you really want to purchase a title, get the Blu-ray or DVD
40four··on The war on terror primed America for autocracy
If you think radicalization is only a problem on the side of Team Red and not so for Team Blue, I would urge you to reevaluate your opinion.
40four··on The war on terror primed America for autocracy
It’s an interesting question if we are more polarized now than at some point in the past. Hard to say, I wonder if there is some way to measure this? Maybe you could compare the amount of “undecided” voters over time.

You always here people say one half of the country is red and the other half is blue, but in reality is probably more like 1/3 each red/blue and another 3rd who don’t subscribe to the dogma of either side and are fed up with the endless bickering between the two teams.

One thing that’s for certain is the tech giants tech giants and news companies are attempting to manipulate us more than ever. It might feel like we’re more polarized that ever, but I think much of that is because it’s good for business, and they are shoving division in our faces on a daily basis.

There is real evidence of this by an awesome project called “Tech Watch Project” (https://techwatchproject.org/). They have a data dashboard with real time charts at https://americasdigitalshield.com/.

The idea is that tech giants are purposely trying to manipulate voters in the middle by feeding them more biased search results, notifications, et cetera. The thing about this, is that on close election they can literally swing elections the way they want them to go by manipulating undecided voters algorithms.

In elections with wider margins it’s not going to have an effect, but in close races it only takes a point or two to get the desired result. This is a power they should not have and it needs to be talked about more.

40four··on Polymarket has flooded social media with deceptive videos by paid creators
In general, so is sports betting at a casino. It seems many people don’t understand this. You aren’t betting against the casino, you are betting against the other gamblers. The house “wins” because of the juice, eg. even odds past out -110. A smart book is going to try to keep the money balanced, but that’s not always the case in practice
40four··on Deno Desktop
Deno continues to impress me. It’s honestly been quite a while since I started a new project without it. It has fully won my support over Node.js, the ecosystem has really matured nicely. I don’t know how often I’ll use this feature, but it’s really nice to have the option!
40four··on Apple's weird anti-nausea dots cured my car sickness
Exactly. It seems to me it has to do with some sort of weird disconnect in our brains of feeling the motion of the vehicle, and what we are visually seeing with our eyes.

This is why I prefer to be in the driver seat at all times if possible. If you’re driving you’re in full control of everything & you’re intensely focused on all the surroundings. Absolutely zero motion sickness for me.

Front passenger seat of a four-door vehicle, you’re still pretty focused on you’re surroundings, but you have no control so unexpected movements can trigger this or looking at your phone/book/magazine or whatever intensifies the effect.

Sitting in the backseat is even worse, much more limited visibility. Sitting in the back of the bus like you said? Way worse, add to the fact that bus drivers tend to be pretty crappy, game over! Public buses absolutely destroy me as well. The only thing I can recommend is to stare outside the window and focus on things in the distance as much as possible.

40four··on Hyundai buys Boston Dynamics
I don’t disagree. Many times when I’ve checked the source links a language model provides, I get concerned. It’s definitely important to stay vigilant and exercise critical thinking, but the model’s ability to synthesize information and converse with it in natural language still blows my mind sometimes
40four··on Midjourney Medical
This is a bit of a contrived example. The “megabytes per second per dollar” is clearly in reference to their scanner technology that the say generates terabytes worth of data, with the goal of a scan taking around 60 seconds. So I’m confused about exactly what your point is?

That’s a lot of data really fast, so if you want this 3D scan of your body, yes, you do want as much data as fast as possible. 60 seconds sounds great compared to an MRI that’s going to take 15 minutes minimum & up to an hour or more.

If you don’t want then scan then carry on as usual.

40four··on Apple's weird anti-nausea dots cured my car sickness
Yeah that makes sense, rapid onscreen movement, but your surroundings are fixed. I feel like you hear of that version less often, but it interesting it basically the inverse of the other kind.
40four··on Apple's weird anti-nausea dots cured my car sickness
That’s unfortunate. I didn’t know this feature existed so I’ve yet to try it out. Fingers crossed
40four··on Apple's weird anti-nausea dots cured my car sickness
Never knew this feature existed! I’ve gotten this type of motion sickness my whole life, so I’m excited to try it out. It would be nice if it’s effective for me.

I get the same type of nausea described by the author. I can’t read a book or look at a screen for too long without a feeling awful. I can also get it just from sitting in a rear passenger seat, especially if vehicle has poor visibility, and even worse with a bad driver. I have to really focus on looking outside the vehicle at the moving world.

Interestingly, I think there are people that have the opposite type of motion sickness. For example, my mom could never play arcade racing games without getting nauseous. The issue being focusing on a screen with rapidly moving objects and everything else in the peripheral being fixed, versus focusing on a fixed object and everything in the peripheral moving. She never had any issue reading a book in a moving car

40four··on Catastrophic DoorDash Outage
I’ve only seen a few smaller short outages before. Never seen the whole system go down across the board like this one thing that’s really awkward is that there’s tons of drivers that were called with active orders, wondering what they’re supposed to do what a nightmare.
40four··on Catastrophic DoorDash Outage
The whole system has been down across the board for going on an hour (at time of posting)
40four··on Iroh 1.0
I’ve recently become somewhat obsessed with a couple of hobby projects that focus on local first, decentralized architecture that sync data between users p2p & that’s how I stumbled across Iroh. It really seems like a great project, and as far as I can tell, if you want to do anything with p2p in 2026 you’re going to hard pressed than to find a better option than Iroh. Really exciting to see a 1.0 release! Congrats to the team!
40four··on Iroh 1.0
I’ve recently been building some hobby projects that focus on local first, decentralized architecture and that’s how I discovered Iroh. In my apps, I want the user data to be stored local only, no server, and have p2p sync ability. So for something like that, Iroh appears to be the state of the art.
40four··on Improvement in advanced Alzheimer’s disease following high-dose psilocybin
I think the Rogan hate has gone too far. I don’t really get it. I’m mean I do, I just disagree. It’s just entertainment. I learned about an interesting person I’d never heard of before, and had fun listening a conversation about unusual topics I’d likely have never found anywhere else. Now I can read that guys books and look more into what he’s doing because I’m curious and find what he’s doing fascinating. It’s really nothing more than that
40four··on Improvement in advanced Alzheimer’s disease following high-dose psilocybin
I’m a skeptical person to, you should be skeptical, it’s healthy! I just find guys like this super interesting and it was a really fun listen.

He talked about how his whole career he just followed whatever was most interesting to him at the time, hence the different disciplines. He also talked about programs he ran at universities where he was in charge of bringing different disciplines together & the challenges of that since academia is incredibly siloed. Departments don’t talk to each other.

So I think people like him are very valuable, since they aren’t afraid to think it if the box, work on taboo subjects like “psychic” abilities, and see the universe in novel ways.

He mentioned they’ve done trials in mice and chimpanzees with very positive results. I’m not saying it’s some crazy breakthrough or anything, but it’s interesting and something worth keeping an eye on. It sounded also like the killer feature is the nasal delivery tech. I don’t think the are the first ones to study non psychoactive psilocybin like compounds, but the nasal delivery that can cross into the brain directly seemed important.

40four··on Successful Psilocybin Treatment of Alzheimer
Hey, fair enough. I don’t necessarily disagree with you, anything with psilocybin in the title tends to be a little more sensational. I find it very interesting though, I just listened to a recent Rogan podcast with Dr. Dean Radin, this exact case study came up because one of his companies is working a related product. Apparently they’ve developed a nasal delivery system that directly crosses into the brain, and the drug uses the same receptors as psilocybin but without the psychedelic effects. Apparently it has extraordinary positive effects on memory and lasts for months. They’ve tested on mice and chimpanzees, so real science is being done in this lane outside this case study. I guess I’m saying sometimes when “traditional” science gets stuck in the mud, we need creative & bold people who think outside the box to move things forward.
40four··on Improvement in advanced Alzheimer’s disease following high-dose psilocybin
Sure, It’s a single case study so obviously take it with a grain of salt. Actual scientists understand this. People on social media don’t ands that’s annoying I get it.

On the other hand, it’s interesting and perhaps illuminating to people working in that field. A field mind you, that has made a little to no progress in decades. Arguments could be made they’ve made some errors and went down the wrong path. It’s a field that could probably use some new ideas.

40four··on Improvement in advanced Alzheimer’s disease following high-dose psilocybin
It’s a single case study so obviously take it with a grain of salt. On the other hand, it’s interesting and perhaps illuminating to people working in that field. A field mind you, that has made a little to no progress in decades. Arguments could be made they’ve made some errors and went down the wrong path. It’s a field that could probably use some new ideas.
40four··on Improvement in advanced Alzheimer’s disease following high-dose psilocybin
This exact case study came up on a recent Rogan episode with Dean Radin, PhD. While the result is very interesting and perhaps illuminating about the unexpected biological mechanisms, apparently the effects were very short lived.

Even more interesting, Dr. Radin discussed one of his companies is working on a new drug that uses the same brain receptors as psilocybin, that has the potential to induce similar effects (with no psychedelic side effects) with a nasal delivery system that crosses directly into the brain. The benefit of that, he says, is the effect would last for much longer, months perhaps, and patients would only have to take it a few times per year.

40four··on Why Is Claude Turning into an a**Hole?
Oh yeah? Go try Grok on “argumentative” mode and come back and tell me Claude is an a-hole. I forgot I was experimenting with the personalities and hadn’t used it in a while, then I picked it up again the other day and I was really confused. It’s so aggressive :)
40four··on Scientists ejected from diabetes conference for distributing journal reprints
Ask the American Diabetes Association. Their conference, their rules. Do people really believe the ADA is a puppet of the administration?
40four··on HHS is overriding peer review to require changes to research scope, design
I read it all. But like many of these science.org articles they are pretty short, and not of the best quality in my opinion. The article itself admits the practice isn’t widespread. It sounds to me like there are a few disgruntled folks on the research side because of some unexpected/ unwanted back and forth in the “commenting” phase of the research? I’m not going to act like I know the mechanics of how research projects like that progress, but it doesn’t sound like it was more than a road bump and then the projects continued after said commenting. No projects were defunded or cancelled as per the article. Were the government commenters out of line or uninformed? Sure that wouldn’t shock me. Does that equate to “HHS is overriding peer review” on some grand systematic level? Seems like a big jump to me, and I don’t feel like the article demonstrates that, but I’m open to other ideas if you see it differently
40four··on MacBook Neo is so popular that Apple doubled production
My first Mac was the same white plastic one, I think it was called the iBook back then? Cost me the majority of my summer job earnings going into freshman year, but it was a great machine for me back then! I still have it in a box somewhere in the basement, might be fun pull it out and resurrect it :)
40four··on Gmail thinks I'm stupid, so I left
Yeah I don’t use it for navigation, but for exploring your local area, finding restaurants, retail or other businesses it’s hard to ignore unfortunately
40four··on Gmail thinks I'm stupid, so I left
Yeah that makes sense, I didn’t consider advertising
40four··on HHS is overriding peer review to require changes to research scope, design
It’s not a “factual” title.

The actual title of the article is “Exclusive: HHS is now weighing in on science in NIH grants”. As if they’ve never done that before? That’s literally one of HHS’s jobs.

The subtitle of the article is “Staffers say comments coming after NIH’s own approvals are overriding peer review”.

Are you arguing “HHS is overriding peer review to require changes to research scope, design” means the same thing as that subtitle? Brushing aside the fact that we’re talking about comments coming after projects were approved?

The submitted title is editorialized to illicit a bigger response that the real tile would have, pretty cut and dry. And the content of the submitted article itself is very shallow.

You’re right, I personally got emotional about it. But that doesn’t prove “it is because it is an accurate portrayal of a bad thing”.

You didn’t care to comment on any of my other points besides the title, I’m happy to get feedback on those specific points as well :)

40four··on HHS is overriding peer review to require changes to research scope, design
Absolutely. Literally in the fourth paragraph it says:

“The number of NIH grants in which HHS has demanded changes is unclear, although the practice does not appear widespread. And Science has not learned of any specific proposal that was not funded as a result. Still… “

40four··on HHS is overriding peer review to require changes to research scope, design
To start, the title doesn’t match the article title, and it’s purposely manipulated to invoke a certain feeling, completely against HN guidelines.

Moreover, a quote from the fourth paragraph:

“ The number of NIH grants in which HHS has demanded changes is unclear, although the practice does not appear widespread. And Science has not learned of any specific proposal that was not funded as a result. Still… ”

Well here we are. You can just stop reading at that point since you know you’re in the middle of a sloppy, politically motivated hit piece. I’m not a Trumper, never voted for him, but it’s clearly invoking anti-Trump sentiment.

Meanwhile HHS isn’t Trump, It’s RFK Jr, and I’ve followed him closely for a long time. Wasn’t super happy about him joining the administration, but I truly believe he did it as an opportunity to make an impact according to his own values. Did you know HHS has the biggest budget in the government? Even over defense?

We’re already seeing the results. Numerous products on the grocery isles already changing their labels and ingredients. I literally just bought a bottle of Gatorade the other day with a flashy label touting “75% less sugar and by artificial dyes”.

The whole 32 ounce bottle only has like 10 grams sugar, and it was still delicious! That’s what Gatorade should have always been, it doesn’t have to be poison to be good or sellable.

We are seeing similar things across the board in the grocery isles, and it will only continue while RFK is at the helm. We should be applauding this, and we should be able to separate it from political dogma.

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