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Alex3917

30,632 karma · joined February 23, 2007

Co-founder @ FWD:Everyone (www.fwdeveryone.com)

https://alexkrupp.typepad.com

https://twitter.com/alexkrupp

alex.krupp@gmail.com

[ my public key: https://keybase.io/alex3917; my proof: https://keybase.io/alex3917/sigs/fCFh_z2Dnx_9agwhK41ieQePaxwifpCJ9zpwDbWrTD4 ]

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Alex3917··on An unused nuclear power plant became home to a world-class acoustics lab
> Does the world-class acoustics lab earn so much money, it can upkeep the industrial facility its housed in?

Obviously not, but there isn't much else the space can be used for. Power plants are extremely polluted because the PCBs from the turbines and transformers drip into the concrete floors and stay there forever, so these spaces generally can't be repurposed in any meaningful way.

Alex3917··on Let's Ban Billboards
This is what Adbusters has been supposed to be advocating for for decades. Except for that instead of just focusing on getting ads banned, they switched focus and started complaining about George W. Bush instead. And that is why we still have billboard advertising to this day.

It's the best case study I know of on the importance of just sticking to your one issue and not getting caught up trying to fix everything else that's broken in the world.

Alex3917··on The Toyota Prius transformed the auto industry
The problems with the Prius are basically:

  - Terrible in snow and ice
  - No way to defrost your windshield, unless you're already driving
  - Poor rear window visibility
If not for those things it would be great, but unfortunately they've made zero progress on fixing any of the core issues for the last 25 years. The new models definitely do look cooler, and I appreciate that they accelerate faster, but I personally care much more about the stuff that could potentially kill me when I'm driving.
Alex3917··on Does current AI represent a dead end?
> Giving them an LLM to help with syntax errors, at this stage of the tech, is deeply unhelpful to their development.

I mean if the alternative is quitting entirely because they can't see that they've mixed tabs with spaces, then yes, it's very very helpful to their development.

Alex3917··on Does current AI represent a dead end?
> code-aware editors have been a thing since the 90s

These will do things like highlight places where you're trying to call a method that isn't defined on the object, but they don't understand the intent of what you're trying to do. The latter is actually important in terms of being able to point you toward the correct solution.

Alex3917··on Does current AI represent a dead end?
> The big difference with LLM AIs is they never graduate to an experienced staffer, they are always the idiot savant that is really dang smart but also clueless and needs to be observed.

Basically this. They already have vastly better-than-human ability at finding syntax errors within code, which on its own is quite useful; think of how many people have probably dropped out of CS as a major after staying up all night and failing to find a missing semicolon.

Alex3917··on What is metformin's secret sauce?
There aren't any papers that I know of on metformin and PSP, but there are lots of papers on rotenone/acetogenins and PSP.
Alex3917··on What is metformin's secret sauce?
> the leap from "mitochondrial complex I inhibition is associated with PSP" to "metformin causes PSP" is unwarranted

The mechanism of action is relatively straightforward: the inhibition is caused by a building up oxides within the mitochondria, which makes them less efficient at producing energy. And if the mitochondria go long enough without a mitochondrial antioxidant clearing out the oxides, they eventually die. And if enough of the mitochondria within your brain die, you get PSP.

My best guess as to the reason we haven't seen an association between PSP and metformin is that metformin is actually a mitochondrial type I adaptogen rather than a mitochondrial type I inhibitor. I'm definitely not telling people not to take it, but if you are then I think setting a couple Google scholar alerts would be prudent.

Alex3917··on What is metformin's secret sauce?
> metformin blocks a specific part of the cell's energy-making machinery called mitochondrial complex

Keep in mind that any mitochondrial complex I inhibitor that is sufficiently strong is going to cause PSP if you take it for long enough, which is basically a fatal and untreatable version of Parkinson's disease. I haven't seen much research on this being a risk specifically for metformin, but I'd be careful about trying to use it prophylactically for longevity purposes rather than for a specific medical condition.

Alex3917··on The Antikythera mechanism – 254:19 ratio
If you're in Athens, the Herakleidon museum has not only an exhibit about this, but about all sorts of other advanced Greek technology: coin-operated vending machines, drink-serving robots, water-powered telegraphs, etc. While this specific device may (or may not) have been a one-off, it's undeniable that ancient Greece was basically the real-life version of a Steampunk-based society. (With the caveat that ancient Persia probably had similar technology at one point also, but most of that has since been destroyed by the British and others throughout history.)
Alex3917··on Honeycrisp apples went from marvel to mediocre
SnapDragon is a vastly improved version of Honeycrisp anyway. The only real issue with it is that only growers within New York State are allowed to grow it, so it's not nearly as available.
Alex3917··on The Engagement Is Better on Bluesky
> Engagement will always be better on new platforms

The primary effect is that communities with fewer users have stronger common bonds, the age of the platform isn't super relevant.

That said, the engagement on Twitter has been terrible since almost the very beginning. I'm sure it was super magical for folks who were at SXSW that first year, but the conversion rate has been garbage ever since then. Whereas maybe 50% - 70% of people will open the average cold email, the percentage of people who will click a link on Twitter was maybe 1 in 1,000 even 10+ years ago.

Alex3917··on The EdTech Revolution Has Failed
> the problem I have seen is no one in education is willing to ACTUALLY let kids learn at their own level.

OK but we've known this since, when, the 60s? Look at all the academic research on the adoption (or lack thereof) of programmed instruction, programmed learning, etc.

If we didn't already know this before the "EdTech Revolution" then of course the industry would get a pass, but the fact that we already knew what would happen and why is what makes it a scam.

Alex3917··on Ask HN: Your thoughts on Linus Torvalds' view on AI: 90% marketing, 10% reality?
> Code examples generated by LLMs CANNOT work without supervision and review of an experienced engineer.

While the code generated by AI is generally garbage, I would note that it often has better-than-human debugging ability. If you copy-paste a function that isn't working, it can often figure out what you were trying to do and then explain what you are doing wrong and how to fix it.

Alex3917··on The almost-lost art of rosin potatoes
> Why would anyone eat fugu or collect wild mushrooms?

I can't speak to fugu, but collecting wild mushrooms is statistically one of the safest hobbies in existence.

Alex3917··on Gross Apple Marketing
> I'm, personally not a fan of the current generation or implementation of AI and do not want to use it.

Why not? It gives vastly better than human performance across a wide range of problems. Just this morning I asked Chat GPT to find me the smallest set of positive integers whose median is 2 and whose average is 3.75, and it just spit out the correct answer instantly. That would have been an enormous pain in the ass to figure out how to do manually, but instead I got it done while in the middle of packing my kids' lunches for school.

Alex3917··on Stars Reach – new social sandbox MMO by Raph Koster announced
I'm surprised the webpage and FAQ doesn't answer the single most obvious question: does this support player housing?
Alex3917··on Cold brew coffee in 3 minutes using acoustic cavitation
I hope the creator does another run of the original Sora Pot, I would buy that in a heart beat.
Alex3917··on Krazam OS
Fireship is very different, but also highly worth a subscription.
Alex3917··on Old part of International Space Station lands on family home
Reminds me of this old Yahoo commercial:

https://www.youtube.com/watch?v=MxsftGNpFaI

Alex3917··on After AI beat them, professional Go players got better and more creative
> I've read about KGS but I've never figured out how to engage with it.

Just download CGoban, here is the website:

https://www.gokgs.com/

Most of us started who are still active on the server have been playing there 20+ years at this point. E.g. I myself (and many others) started playing after reading this article:

https://tromp.github.io/gostory.html

Alex3917··on After AI beat them, professional Go players got better and more creative
> When you read Go strategy resources, you see a lot of things divided into what best practices were before AlphaGo and what they are now. It's a whole big thing.

Yes and no. The biggest takeaway from AI is that learning all the joseki doesn't actually matter that much, which has freed up players (except for the pros) to spend more of their time focusing on the more fun and interesting parts of the game.

There are a lot of videos showing what josekis and strategies the AI recommends, but as a human you're likely not going to be any better off following them. This is for the same reason why AI analysis of fights is largely useless. That is, the reason why you lost the big fight (and the game) isn't that you didn't find that one obscure 9P move that could have saved you, but rather than you let yourself get cut 50 moves earlier. But the AI will never show you the move where you got cut as being the reason why you lost the game, it will only show you the one random move that you'd never in a million years actually be able to find.

This video from Shygost sums up the most important strategy stuff that you actually need to know in order to get strong: https://www.youtube.com/watch?v=ig8cWuDSHTg

Alex3917··on After AI beat them, professional Go players got better and more creative
> I wish the AGA was more supportive of it rather than KGS.

Out of curiosity, why do you like OGS more? I find the UX of KGS to be way more intuitive.

Alex3917··on The largest deep lake water cooling project just got bigger
> The article says that the water is returned to the lake at about the same temperature that it leaves...though I'm unclear how that's possible.

The most plausible explanation is that the article is wrong, and that the author meant to say that the lake is about the same temperature as it was before. Which is generally true; although the water being returned is slightly warmer, once you get more than a few meters away the difference is negligible. There is a ton of research on this phenomena with respect to the lake source cooling plant in Ithaca, because people obviously had the same concerns about that one before it was built.

Alex3917··on For Brilliant Color: Packaging the First LSD Blotter
Great article, makes me want to finally read the author’s Techgnosis book which has been on my shelf forever.
Alex3917··on Django REST framework 3.15.0
No, but you don’t need to use the built-in serializers. Just swap them out for Marshmallow.
Alex3917··on Deadly morel mushroom outbreak highlights big gaps in fungi knowledge
The commercial button mushrooms are still carcinogenic when eaten raw. The reason you see them at salad bars is because in practice there is no way to sue the salad bar if you get cancer 20 years later or whatever. But it's still not a good idea to eat them raw.

The only two mushrooms people generally recommend trying raw are the beefsteak polypore and the caesar's amanita. But this isn't because they are healthier when eaten raw, but rather because they have some unique culinary properties that are considered worth the risk when consumed in small quantities.

Alex3917··on Deadly morel mushroom outbreak highlights big gaps in fungi knowledge
> On April 8, the morels were served partially cooked, with a hot, boiled sauce poured over the raw mushrooms and left to marinate for 75 minutes; and on April 17, they were served uncooked and cold-marinated.

All morels are poisonous when eaten raw. There is zero gap in knowledge here.

Alex3917··on Why are there so many methane satellites?
FWIW this video has a good explanation of why this new satellite was launched:

https://www.youtube.com/watch?v=rhWcFShBAFE

And this New Yorker article has a much more detailed explanation:

https://www.newyorker.com/news/annals-of-climate-action/a-se...

Alex3917··on Sam Altman seeks to raise up to $7T for new chip project
Even if the gulf states had the money, they still wouldn't do it. The main thing they care about is decreasing their risk of having their assets frozen by the U.S., which is why they are happy to make money-losing investments. Whereas investing this much into a single venture would massively increase their exposure.
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