How many Mac Pro's have ever sold? Or the Pro Display XDR that costs more than the Vision Pro... Apple are in the business of generating hype and a ladder of hype and glam around what would otherwise be boxes of electronics. They then sell millions at the bottom end whilst everyone aspires for debt to buy the high end.
That's a different meaning of endosymbiosis at a more macro scale. This is cellular endosymbiosis. Having bacteria in your gut is not the same as having them be integrated at a molecular level into your cells as an organelle. You're scepticism of the media hype claim is correct though, there are other well known examples of endosymbiosis like this occurring, primary and secondary. Perhaps not primary with cyanobacteria but thats hardly some huge "scientific leap" in understanding or astonishment compared to some of the other stuff we know about.
Ironically you do see this kind of cellular endosymbiosis amongst the endosymbionts within insect guts with the most extreme example probably being Mixotricha paradoxa https://en.wikipedia.org/wiki/Mixotricha_paradoxa
Hatena arenicola https://en.wikipedia.org/wiki/Hatena_arenicola is very similar to this new finding, but with an algae instead of a cyanobacteria so its a secondary endosymbiosis which if anything is actually more interesting and bizarre.
We also know from the genome of Smybiodinium that its undergone quite a few endosymbiotic capture events some secondary with algae but quite likely some primary with bacteria too https://en.wikipedia.org/wiki/Symbiodinium
The main issue is the majority of managers arent especially qualified to make a judgement of the code itself which makes the metric spurious at best. Lines changed is at least a better version than lines added. But it is fairly devoid of meaning removing ten lines can be extremely hard and impactful compared to adding 1000 lines of deeply nested ifs written poorly. Lines changed multiplied by number of files touched is possibly better too.
Valid comment, unless $is_bad_example. I genuinely really like the use of unless in Perl. There are lots of times it's nicer to express inverse logic. You could change the name of a variable to have inverse truthyness and not have if not everywhere. Or you could accept you often need to deal with inverse logic on something and use the right language.
I'd say this is more like pytorch is horribly packaged and a nightmare as an eng user to integrate into codebases. All of their assumptions are you use conda and are a datascientist one time doing something in an ipython notebook. Very little consideration is made to how you deploy at scale reliably. It's not really on poetry.
There are proteins known as "Intrinsically Unstructured Proteins" or "disordered" proteins. That function with no fixed configuration. Typically a good way of thinking about them is an ensemble of transient more common states, where things like post translational modification alters how long and which conformations the protein visits. The other replies you've gotten are inaccurate and about 15+ years out of date in thinking about protein structure.
Think of a roiling noodle where sections or the whole thing linger in certain shapes and configurations longer than in other positions.
Right... but the title before the first line reads "DataFrames for the new era". If you don't know what a data frame is then, yes, it's for people who already know that.
I'd say you're pushing from flippant to disrespectful on the who and how of this being done. Starting with you've got Addenbrooks and Guangzhou hospitals collecting the foetal material that will have been lovingly donated from some of the most distressed members of the British and Chinese population. The pipeline although commodity came from a new startup Enhanc3D Genomics Ltd (inc. 2020). Over 15 labs worked collaboratively to build the atlas of results, because the expense in human time alone far exceeds what could be done in a single lab.
I suspect a lot of the back to brick is actually more phase one of dealing with damp. Once its dried out a lot of houses in my area then go and get coloured insulating render. So it's not even paint anymore but the actual material is coloured.
That was already and always the function and value of a university... Notice the academics aren't sitting in lectures 6 hours a day or trying to pass exams to obtain degrees. They're the longterm users of universities and educating themselves their entire lives.
Why would a teenager bother going to college, if the society they live in is decaying and doesn't even maintain capabilities it held three generations prior. Especially if the communicated focus from their parents is to only ever worry about feeding grandma and driving a car.
It's more GNU Parallel has host groups in a config so you can send files for a job to the right one where its going to execute and bring things back. Essentially it can turn a local xargs type job into any kind of remote task execution including dealing with files locally needing to be remote.
Tobacco isn't a model organism at all. Solacea genomes only really got sorted in the late 2010s. Its worth pointing out if you could do something in Tobacco you could have done it in Tomato or Potato, you know those crops that dont kill people globally but sustain them. Arabidopsis thaliana (a type of cress) is the small plant model organism, not because it's biologically significant, but because it had a tiny diploid genome that could be mapped early and it's easy to grow quickly in a lab and seeds fast.
Lots of people discussing tech or quality reasons for the decline. I'd like to suggest something far worse, there is a huge decline in the number of junior professionals in our field due to global economic pressures. There are less people needing to ask a question because they already know the answers.
A more unique selling point is having an easily and widely serviced ebike since its complexity and serviceability is worse than a normal push bike for ordinary people. You can get trackers for most other ebike systems.
The point that flew over your head is every one wants one spice rack. There is no scale, no one wants a 1km long spice rack or 10,000 small ones either. That you can just buy a ready made one is even more to the authors point. Most software shouldnt exist! Why even build a spice rack, indeed!
I have a book upstairs I authored that I can go to and be reminded there was a moment my mind was like a samurai sword for one very specific problem. I solved it by holding a thought in my brain consistently for ~3 years straight, and trying everything known and new tricks to solve it. I can barely read my thesis anymore, let alone understand it, the quality of what I did feels almost super human compared to what I've been asked of by the world outside academia. A lot of people who never spent any time post undergrad think its all nonsense, mostly because they meet slacker types. But if you really challenge yourself you will produce something singular and at the best of your ability. It's extremely rare you get that opportunity and support in time to do that anywhere else. Unless your PhD translates to commercial application directly! Perhaps artists with healthy commissions get to feel it. Startup life is similar I guess, but the pressure of commercial success is a very different driving force vs intellectual curiosity and understanding something new in the world. Post PhD I know that if I felt like it I can operate at an incredibly high level intellectually, that I choose not to post PhD is also the other confidence PhD gives you. Most people I know are pretty down to earth post PhD and leaving academia, its ultimately a humbling experience especially if you had fun with mental health during getting it done. You know you can do something, but you also know at what cost to yourself and people around you.
There is also a hidden variable about being tired too, and if you don't slack off you waste months in forced situations with asking for breaks with the supervisor or burning out.
That reasoning feels a bit like saying only tens of millions of smart phones will sell because rotary dial telephones have been around since the 1890s. I think its very fair to say the Quest and PSVR and all their friends are a big leap from Nintendo's Virtual Boy or something. Enough we should consider it a different market for sure. The real issue is software still to this day utterly sucks. There is zero incentive for existing games companies to make content until the market is as large and easy to port to as the existing status quo. The difference with 3D accelerated screen base 3D games was the entire form of entertainment was new and clearly valuable. Too many business people think VR is just another medium for existing 3D games, which also means its being treated like a new console or something with respect to investment. The barriers to entry for plucky homebrew creating something of super high quality is also much much higher than the start of 3D games. Valve already demonstrated what the good end of experiences can look like, even on older gen of VR hardware, but also demonstrated it takes a seriously talented team given total freedom to produce the best with investment behind them. Augmented reality who knows, metaverse type VR who knows. But we haven't even seen the basic uptake of high quality AAA VR software because it doesn't exist regardless of how good a headset is. It's like if a smartphone could only act like an analogue mobile phone and everyone questions the hardware being important.