arijo

Possess is a strong word - nevertheless you can start here if you want to be aware of what is going on in the real world:

Youtube Videos

https://youtu.be/PeqQd4_xveI?t=43

https://youtu.be/G0lTyhvOeJs?t=421

https://www.youtube.com/@metabolicmind

Books

https://a.co/d/cUAgokV

https://a.co/d/32zSKzo

https://a.co/d/acVla0y

Ozempic, Wegovy, and Mental Health: Are GLP-1 Drugs Linked to Suicidal Thoughts?

https://www.youtube.com/watch?v=izqKRo3e31E

"Yes. I'm a T2 diabetic and have been on an SSRI for years. A couple years ago I was trying to up my dose of Ozempic, as prescribed. Perhaps it was coincidence, but over time I sank into a deep depression and I simply felt like the only reason not to k*l myself was I could never do that to my family. I also developed panic attacks. More fun than a barrel of monkeys! Since then, I've drastically reduced my carbohydrate intake, stopped the Ozempic, and basically made an almost complete recovery. I haven't had a panic attack in two months, and it was mild."

"Dear Dr Scher. I can confirm a very serious major depressive reaction to Saxenda/Liriglutide. This happened 2 days into 1.8mg dose which was exactly when my appetite diminished. Very, very disappointing . This was in spite of taking long-standing Venlafaxine/Effexor, which for this reaction was useless. After stopping Saxenda, my mental state took about 10 days to restabilize. I trust this may be of help to other"

"

Not wrong in my personal case - I've lost those 20+ kilograms with no problem to report.

Again, it was not a calorie restriction diet - it was a carb restriction diet.

Report results you mentioned -> https://catalogues.ema.europa.eu/system/files/2024-03/FINAL_...

"This study was not a random control trial. It was a comparative cohort study, which is an observational study design.

In a randomized control trial, participants are randomly assigned to different groups, with one group receiving the treatment being studied and the other group receiving a placebo or a different treatment. This allows researchers to determine whether the treatment is effective by comparing the outcomes of the two groups.

In a cohort study, researchers observe a group of people over time to see if there is a relationship between certain exposures and outcomes. Participants are not randomly assigned to groups. The study in the source is specifically a comparative cohort study with an active comparator, new user design.

This means that researchers are comparing the outcomes of two groups of patients: those who are new users of GLP-1 receptor agonists and those who are new users of SGLT-2 inhibitors.

The active comparator is the SGLT-2 inhibitor group. This group is used as a comparison to the GLP-1 receptor agonist group to help researchers determine whether there is an association between the use of GLP-1 receptor agonists and an increased risk of suicide-related and self-harm-related events. It is important to note that cohort studies, like the one described in the source, can only show an association between exposures and outcomes. They cannot prove that one thing causes another."

"Therefore, while the study aims to contribute valuable insights into this potential safety concern, its design and inherent limitations preclude it from making definitive causal statements. Even if the study finds no association, further research, potentially using different methodologies, would be needed to strengthen the evidence and confidently assert that GLP-1 receptor agonists do not causally increase the risk of suicide-related and self-harm-related events"

Taking this into account I'm still going to stick with my ketogenic diet, thank you very much.

I'm unfortunately expecting this getting worse with massive adoption of the drug but we can start with "Risk of Suicidal Thoughts and thoughts of self-harm with medicines known as GLP-1 receptor agonists,1 including Ozempic (semaglutide), Saxenda (liraglutide) and Wegovy (semaglutide)" - https://www.ema.europa.eu/en/news/ema-statement-ongoing-revi...

By the way - why are you so eager to promote this drug - can you please declare any conflict of interests?

Every drug has long term side effects but people are being sold GLP1 as a miracle weight lost pill when the focus should be on reducing all the toxic junk food that is causing the weight gain in the first place.

And yes, many research programs are funded by pharma - the conlict of interests is blatant and getting more people sicker every year.

Honestly, I’m pretty sure you’re very aware of all this so I question your motivations to be openly promoting a drug that interferes directly with cellular metabolism like if you’re selling candy.

In contrast with the huge amount of money that the pharma industry spends in marketing GLP1 drugs to people not caring about their long term effects but only on profit.

I wish there were more Casey and Calley Means in this world instead of ever more metabolic and mentally ill society living more like zombies than free human beings.

That’s not true - the ketogenic diet is not a calorie restriction diet. It was invented early last century by a medical doctor to simulate fasting and treat epilepsy in children. Low calorie diet lead to yo-yo dieting which is not the case for keto were you are allowed to eat enough calories to be satiated. The binge eating comes for the oscillating glucose and insulin levels driven by the consumption of refined carbs. Carb addiction is the problem and that’s the root cause we should be addressing to stop the metabolic health epidemic that has only been getting worse despite all the pharma profits.

Not if you start from an extremely obese starting point like I did. I don’t recommend this rate to people with normal weight.

I know this going to be blasfemy but the real problem here is carb addiction and we should be treating the root cause not the symptoms with a drug with unpredictable long term consequences.

Yes I actually used ChatGPT to calculate what would be the required daily amount of calories to achieve my target weight in 6 months - the big difference is I always feel satiated and that the body being in ketosis ensures I’m not accumulating but burning fat.

If your primary macro consumption is fat, your body will enter a state of ketosis burning fat instead of glucose. As long as your calorie intake of fat is less than your basal metabolism corrected by some factor, you will lose weight and feel satiated - you do not need to follow a calories restriction. Believe me - I tried both ways and the ketogenic diet never left hungry - always satiated.

I’m fat, I’ve been cooking my own keto meals for more than two months, I’ve consistently been in ketosis and yesterday was my 50th birthday :)

I’m 1.78m, 50 years old, my initial weight 2 month ago before I started the keto diet was 154kg and two months later I’m almost 130kg. Eating the same amount of calories as before.

Implementing a ketogenic diet is not the same as a caloric restriction diet - it’s an inversion of the macronutrient pyramid - heavy on fat, moderate on protein and low on carbs.

Even if you consume the same calories as in a traditional diet you’ll likely lose weight. Check the https://metabolicmind.org site for more insightful information.

I would listen to what his guests on this particular podcast have to say before jumping into conclusions just because the interviewer is Joe Rogan.

I have no particular opinion on him - I’m just interested in what the interviewees in this specific episode have to say about metabolic health which has direct implications on the massive usage of drugs like ozempic.

Check the https://metabolicmind.org site then - you’ll find plenty of research based evidence on the usage of the ketogenic diet as a metabolic therapy.

It really helps if you use some LLM tool like ChatGPT or Claude to generate the keto recipes (sometimes with the ingredients you have available).

If you stick to cooking keto recipes for a few weeks you end up internalizing the recipe patterns and you start cooking without even thinking about it.

It's not a miracle drug. Check this Joe Rogan interview to understand at a deep level all the problems with a drug like Ozempic: https://www.youtube.com/watch?v=G0lTyhvOeJs

I also recommend taking a look at this Joe Rogan interview to understand at a deep level all the problems with a drug like Ozempic - https://www.youtube.com/watch?v=G0lTyhvOeJs

I apologize for the shortcut - I should have given more context, though you can validate my assertion by going to this site: https://metabolicmind.org

There is heavy research on the usage of the ketogenic diet for the treatment of metabolic and mental illness.

I've written about my personal story here - https://www.feelingbuggy.com/p/finding-hope-after-decades-of...

Cut on carbs and you will have all the benefits without the nasty side effects.

Check https://metabolicmind.org for details.

My own experience with the keto diet - https://www.feelingbuggy.com/p/finding-hope-after-decades-of...

I would suggest to use an LLM chat to generate ketogenic recipes - works well for me.

That’s a little too pompous don’t you think?

I’m taking supplements.

I was (still am) very overweight - initial weight aroud 154kg and I’m medium height (180cm)

If it’s possible that some healthy ketogenic diets don't carry the risks mentioned in those 2 papers then by definition there’s an over generalization implicit in the research results.

If there are issues between different ketogenic diets let’s try to figure out what those are without dropping the baby with the bath water.

Why wouldn’t these substantial risks also apply to psychiatric patients - are there any studies corraborating your assertion?

Take a look at this interview with Dr. Georgia Ede MD - she's is an expert on the usage of nutrition for the treatment of mental ilness. In the video (and the book below) she provides a lot of insights about how to start and maintain a medical grade ketogenic diet.

https://www.youtube.com/watch?v=M-iFdXiBObE&t=4s

https://a.co/d/bkDPNT7

Here's your chance to support a research study following all the protocols and procedures that was cancelled unilatery by the state of Maryland - https://x.com/ChrisPalmerMD/status/1807883172454998272

Watch this video for more details on the study - https://www.youtube.com/watch?v=tzPlQ6dJwe8&t=475s